Each player who controls a multicolored creature draws a card. Then destroy all creatures.
Illustrated by Jokubas Uogintas · Streets of New Capenna · #406
There are no rulings for Depopulate.
Each player who controls a creature with power 4 or greater draws a card. Then destroy all creatures.
Each player who controls the most creatures investigates. Then destroy all creatures. (To investigate, create a Clue token. It's an artifact with ", Sacrifice this token: Draw a card.")
Each player chooses a creature they control. Destroy the rest.
Flashback (You may cast this card from your graveyard for its flashback cost. Then exile it.)
Destroy all creatures with power 3 or greater. Then create a Food token for each creature you control. (It's an artifact with ", , Sacrifice this token: You gain 3 life.")
Each player chooses a creature type. Destroy all creatures that aren't of a type chosen this way. They can't be regenerated.
For each player, choose friend or foe. Each friend puts a +1/+1 counter on each creature they control. Each foe chooses one untapped creature they control, then taps the rest.